Phenotypes associated with this allele

• Allele Symbol: Ptk2^tm3.1Guan
• Allele Name: targeted mutation 3.1, Jun-Lin Guan
• Allele ID: MGI:5485069
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptk2^tm3.1Guan/Ptk2^tm3.1Guan	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:5485070
cx2	Ptk2^tm3.1Guan/Ptk2^tm3.1Guan Tg(MMTV-PyVT)634Mul/0	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:5485071

Genotype
MGI:5485070

hm1

• Allelic Composition: Ptk2^tm3.1Guan/Ptk2^tm3.1Guan
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:195658 )

• mice are viable and fertile with normal mammary gland development

Genotype
MGI:5485071

cx2

• Allelic Composition: Ptk2^tm3.1Guan/Ptk2^tm3.1Guan; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Suppressed mammary tumor growth in Ptk2^tm3.1Guan/Ptk2^tm3.1Guan Tg(MMTV-PyVT)634Mul/0 mice

neoplasm

decreased metastatic potential ( J:195658 )

• fewer metastatic nodules than in Ptk2^tm3.1Guan/Ptk2⁺ Tg(MMTV-PyVT)634Mul mice

abnormal tumor morphology ( J:195658 )

• tumor cells exhibit defective epithelial-mesenchymal transition and fewer mammary cancer stem cells compared to in Ptk2^tm3.1Guan/Ptk2⁺ Tg(MMTV-PyVT)634Mul mice

decreased tumor growth/size ( J:195658 )

• tumors grow slower than in Ptk2^tm3.1Guan/Ptk2⁺ Tg(MMTV-PyVT)634Mul mice