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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col1a1tm1(tetO-EWSR1/ATF1)Yasu
targeted mutation 1, Yasuhiro Yamada
MGI:5485192
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(EYFP)Cos
Tg(Mpz-cre)94Imeg/0 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5485201
cn2
 		Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(CAG-cat,-lacZ)11Miya/0 		involves: 129S4/SvJae * C57BL/6 * CBA/J * DBA/2 MGI:5485200
cx3
 		Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ 		involves: 129S4/SvJae * C57BL/6 MGI:5485198


Genotype
MGI:5485201
cn1
Allelic
Composition		 Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(EYFP)Cos
Tg(Mpz-cre)94Imeg/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-EWSR1/ATF1)Yasu mutation (0 available); any Col1a1 mutation (161 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation (12 available); any Gt(ROSA)26Sor mutation (968 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (968 available)
Tg(Mpz-cre)94Imeg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased sarcoma incidence ( J:194505 )
• in of all doxycycline-treated mice arising from neural crest-lineage cells




Genotype
MGI:5485200
cn2
Allelic
Composition		 Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(CAG-cat,-lacZ)11Miya/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA/J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-EWSR1/ATF1)Yasu mutation (0 available); any Col1a1 mutation (161 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (968 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(CAG-cat,-lacZ)11Miya mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased sarcoma incidence ( J:194505 )
• in of all doxycycline-treated mice arising from neural crest-lineage cells




Genotype
MGI:5485198
cx3
Allelic
Composition		 Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-EWSR1/ATF1)Yasu mutation (0 available); any Col1a1 mutation (161 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (968 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:194505 )
• after 3 to 10 months of doxycycline-treated mice with median survival of 20 weeks

neoplasm
tumor regression ( J:194505 )
• in doxycycline-treated mice following withdrawal of doxycycline
increased sarcoma incidence ( J:194505 )
• in the trunks, heads, limbs, and whisker pads of all doxycycline-treated mice after 3 months arising from neural crest-lineage cells

cellular
decreased fibroblast proliferation ( J:194505 )
• in doxycycline-treated mouse embryonic fibroblasts

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
clear cell sarcoma DOID:4233 J:194505




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory