Phenotypes associated with this allele

• Allele Symbol: Cd28^tm1Ltu
• Allele Name: targeted mutation 1, Laurence A Turka
• Allele ID: MGI:5485211
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd28^tm1Ltu/Cd28^tm1Ltu Foxp3^tm4(YFP/icre)Ayr/Foxp3^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5485238

Genotype
MGI:5485238

cn1

• Allelic Composition: Cd28^tm1Ltu/Cd28^tm1Ltu; Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Skin inflammation and enlarged lymph nodes and spleen in Cd28^tm1Ltu/Cd28^tm1Ltu Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ mice

immune system

decreased T cell proliferation ( J:194503 )

• reduced proliferation of T regulatory cells in the thymus but not spleen or lymph nodes

enlarged spleen ( J:194503 )

• at 2 to 5 months with accumulation of activated T cells

increased B cell number ( J:194503 )

• in the lymph node

decreased regulatory T cell number ( J:194503 )

• in the thymus but not lymph node or spleens

• in the thymus and periphery of female mice at 3 months

increased activated T cell number ( J:194503 )

• in the lymph nodes and spleen at 2 to 5 months

• with IFN-gamma expression

enlarged lymph nodes ( J:194503 )

• at 2 to 5 months with accumulation of activated T cells

increased susceptibility to autoimmune disorder ( J:194503 )

• by 8 to 12 weeks with crusting eyelids, facial hair loss, which progressed to hair loss on the trunk, skin lesions, an ill appearance, ruffled fur, hunching and reduced movements

• however, CD28-sufficient regulatory T cells prevent the autoimmune disease development

increased susceptibility to experimental autoimmune encephalomyelitis ( J:194503 )

• 20 days after immunization, mice treated with rMOG/CFA plus pertussis toxin exhibit increased clinical score and fail to recover compared with wild-type mice

skin inflammation ( J:194503 )

• at 2 to 5 months

integument

skin inflammation ( J:194503 )

• at 2 to 5 months

focal hair loss ( J:194503 )

• facial hair loss, which progressed to hair loss on the trunk by 8 to 12 weeks

ruffled hair ( J:194503 )

• by 8 to 12 weeks

skin lesions ( J:194503 )

• by 8 to 12 weeks

behavior/neurological

hunched posture ( J:194503 )

• by 8 to 12 weeks

decreased locomotor activity ( J:194503 )

• by 8 to 12 weeks

vision/eye

abnormal eyelid morphology ( J:194503 )

• crusting by 8 to 12 weeks

hematopoietic system

decreased T cell proliferation ( J:194503 )

• reduced proliferation of T regulatory cells in the thymus but not spleen or lymph nodes

enlarged spleen ( J:194503 )

• at 2 to 5 months with accumulation of activated T cells

increased B cell number ( J:194503 )

• in the lymph node

decreased regulatory T cell number ( J:194503 )

• in the thymus but not lymph node or spleens

• in the thymus and periphery of female mice at 3 months

increased activated T cell number ( J:194503 )

• in the lymph nodes and spleen at 2 to 5 months

• with IFN-gamma expression

growth/size/body

enlarged spleen ( J:194503 )

• at 2 to 5 months with accumulation of activated T cells

cellular

decreased T cell proliferation ( J:194503 )

• reduced proliferation of T regulatory cells in the thymus but not spleen or lymph nodes