Phenotypes associated with this allele

• Allele Symbol: Cldn4^tm1.1Yham
• Allele Name: targeted mutation 1.1, Yoko Hamazaki
• Allele ID: MGI:5485358
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cldn4^tm1.1Yham/Cldn4^tm1.1Yham	B6.129S2-Cldn4^tm1.1Yham	MGI:5485366

Genotype
MGI:5485366

hm1

• Allelic Composition: Cldn4^tm1.1Yham/Cldn4^tm1.1Yham
• Genetic Background: B6.129S2-Cldn4^tm1.1Yham

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hydronephrosis in Cldn4^tm1.1Yham/Cldn4^tm1.1Yham mice

mortality/aging

premature death ( J:195766 )

• some mice die after the first year of life due to hydronephrosis

renal/urinary system

renal/urinary system phenotype ( J:195766 )

N • mice exhibit preserved tight junctions, barrier function in the kidney and response to dehydration

increased kidney cell proliferation ( J:195766 )

• of kidney pelvis and ureteral urothelium

increased urine calcium level ( J:195766 )

• at 3 months

increased urine chloride ion level ( J:195766 )

• at 3 months

abnormal renal/urinary system morphology ( J:195766 )

• mice exhibit preserved tight junctions, barrier function in the kidney and response to dehydration

abnormal kidney pelvis urothelium morphology ( J:195766 )

• diffuse urothelial hyperplasia prior to hydronephrosis

• papillomatous protrusions without overt tumor formation

hydronephrosis ( J:195766 )

• macroscopic hydronephrosis evident in most mice before 10 months with severely compressed renal parenchyma

• unilateral before 15 months

• some bilateral hydronephrosis after 16 months

ureter urothelium hyperplasia ( J:195766 )

• prior to hydronephrosis

abnormal renal reabsorption ( J:195766 )

• impaired resabsorbtion of calcium and chloride ions

abnormal renal calcium reabsorption ( J:195766 )

• impaired resabsorbtion of calcium

abnormal ureter physiology ( J:195766 )

• increased proliferation of kidney pelvis and ureteral urothelium

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:195766 )

N • serum chloride ion levels are normal

decreased circulating calcium level ( J:195766 )

• mild at 3 months

increased urine calcium level ( J:195766 )

• at 3 months

abnormal renal calcium reabsorption ( J:195766 )

• impaired resabsorbtion of calcium

increased urine chloride ion level ( J:195766 )

• at 3 months

cellular

increased kidney cell proliferation ( J:195766 )

• of kidney pelvis and ureteral urothelium