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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Sftpc-rtTA,Nudt18-tetO-cre)1Ptch
transgene insertion 1, Pao-Tien Chuang
MGI:5486022
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Sftpc-rtTA,Nudt18-tetO-cre)1Ptch/0
Tg(tetO-EGFR*L858R)56Hev/0 		involves: C57BL/6 * CBA * CD-1 MGI:5486124


Genotype
MGI:5486124
cx1
Allelic
Composition		 Tg(Sftpc-rtTA,Nudt18-tetO-cre)1Ptch/0
Tg(tetO-EGFR*L858R)56Hev/0
Genetic
Background		 involves: C57BL/6 * CBA * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Sftpc-rtTA,Nudt18-tetO-cre)1Ptch mutation (0 available)
Tg(tetO-EGFR*L858R)56Hev mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:195738 )
• with 12 weeks of continuous doxycycline administration, mice develop widespread tumors in the alveoli, but not in other regions of the lung; tumor cells are highly proliferative

respiratory system
respiratory system phenotype ( J:195738 )
N
• without doxycycline treatment, lung morphology is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory