All Phenotypes Id2<tm1Gtbz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Id2^tm1Gtbz
targeted mutation 1, Gabrielle T Belz
MGI:5486127

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Id2^tm1Gtbz/Id2^tm1Gtbz	involves: C57BL/6	MGI:5486131
cx2	Batf3^tm1Kmm/Batf3^tm1Kmm Id2^tm1Gtbz/Id2^tm1Gtbz	B6.Cg-Batf3^tm1Kmm Id2^tm1Gtbz	MGI:5486201
cx3	Id2^tm1Gtbz/Id2^tm1Gtbz Irf8^tm1Hor/Irf8^tm1Hor	involves: 129P2/OlaHsd * C57BL/6	MGI:5486202
cx4	Id2^tm1Gtbz/Id2^tm1Gtbz Nfil3^tm1.1Brad/Nfil3^tm1.1Brad	involves: C57BL/6	MGI:5486203

Allelic Composition	Id2^tm1Gtbz/Id2^tm1Gtbz
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2^tm1Gtbz mutation (0 available); any Id2 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:195908 )

• mice exhibit normal survival and hematopoietic cellularity and lineage composition

Allelic Composition	Batf3^tm1Kmm/Batf3^tm1Kmm Id2^tm1Gtbz/Id2^tm1Gtbz
Genetic Background	B6.Cg-Batf3^tm1Kmm Id2^tm1Gtbz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Batf3^tm1Kmm mutation (4 available); any Batf3 mutation (18 available)
Id2^tm1Gtbz mutation (0 available); any Id2 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell physiology ( J:194760 )

• in reconstitution assays, CD8alpha+ dendritic cells generate from transplanted bone marrow cells fail to survive long-term

• CD8alpha+ dendritic cells exhibit impaired cell-associated cross-presentation compared with control cells

• however, cells exhibit normal soluble cross-presentation and cell-associated antigen cross-presentation during GVHD or HSV-1 viral antigens

Allelic Composition	Id2^tm1Gtbz/Id2^tm1Gtbz Irf8^tm1Hor/Irf8^tm1Hor
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2^tm1Gtbz mutation (0 available); any Id2 mutation (21 available)
Irf8^tm1Hor mutation (1 available); any Irf8 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal bone marrow cell morphology/development ( J:194760 )

• in reconstitution assays, bone marrow cells are not able to generate CD8alpha+ dendritic cells

Allelic Composition	Id2^tm1Gtbz/Id2^tm1Gtbz Nfil3^tm1.1Brad/Nfil3^tm1.1Brad
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2^tm1Gtbz mutation (0 available); any Id2 mutation (21 available)
Nfil3^tm1.1Brad mutation (0 available); any Nfil3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:194760 )

N	• in reconstitution assays, bone marrow cells are able to generate CD8alpha+ dendritic cells

immune system

immune system phenotype ( J:194760 )

N	• in reconstitution assays, bone marrow cells are able to generate CD8alpha+ dendritic cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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