Phenotypes associated with this allele

• Allele Symbol: Del(17Trem1-Trem3)1Jkt
• Allele Name: deletion, Chr 17, Julia Klesney-Tait 1
• Allele ID: MGI:5486219
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(17Trem1-Trem3)1Jkt/Del(17Trem1-Trem3)1Jkt	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	MGI:5486306

Genotype
MGI:5486306

hm1

• Allelic Composition: Del(17Trem1-Trem3)1Jkt/Del(17Trem1-Trem3)1Jkt
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Del(17Trem1-Trem3)1Jkt/Del(17Trem1-Trem3)1Jkt mice show impaired pulmonary inflammation in response to P. aeruginosa challenge

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:194295 )

• in mice challenged with Pseudomonas aeruginosa

immune system

impaired neutrophil chemotaxis ( J:194295 )

• mice challenged with Pseudomonas aeruginosa exhibit impaired neutrophil migration into airways compared with cells from wild-type mice

• neutrophils exhibit impaired transepithelial migration compared with wild-type cells

• however, neutrophils exhibit normal in vitro chemokine-induced migration and transendothelial migration

abnormal cytokine level ( J:194295 )

increased circulating interleukin-1 alpha level ( J:194295 )

• in mice challenged with Pseudomonas aeruginosa

increased circulating interleukin-10 level ( J:194295 )

• in mice challenged with Pseudomonas aeruginosa

increased circulating interleukin-6 level ( J:194295 )

• in mice challenged with Pseudomonas aeruginosa

increased circulating tumor necrosis factor level ( J:194295 )

• in mice challenged with Pseudomonas aeruginosa

abnormal chemokine level ( J:194295 )

• mice challenged with Pseudomonas aeruginosa exhibit increased chemokine levels in the bronchoalveaolar lavage fluid and lung homogenate compared with wild-type mice

abnormal circulating chemokine level ( J:194295 )

• mice challenged with Pseudomonas aeruginosa exhibit increased serum chemokine levels compared with wild-type mice

abnormal cytokine secretion ( J:194295 )

increased interleukin-1 alpha secretion ( J:194295 )

• in the lung homogenate of mice challenged with Pseudomonas aeruginosa

increased interleukin-1 beta secretion ( J:194295 )

• in the lung homogenate of mice challenged with Pseudomonas aeruginosa

increased interleukin-10 secretion ( J:194295 )

• in the lung homogenate of mice challenged with Pseudomonas aeruginosa

increased interleukin-17 secretion ( J:194295 )

increased interleukin-6 secretion ( J:194295 )

• in the lung homogenate of mice challenged with Pseudomonas aeruginosa

increased susceptibility to bacterial infection ( J:194295 )

• mice challenged with Pseudomonas aeruginosa exhibit increased mortality, hypothermia, plasma alanine aminotransferase, bacterial titer in bronchoalveolar lavage fluid and whole lung, bronchoalveaolar lavage fluid and lung chemokine levels, lung cytokine levels (IL1a, IL1b, IL6, IL10, IL17) and serum cytokine (IL6, IL1a, TNFa, IL10) and chemokine levels but reduced pneumonia and neutrophil infiltration into the airways despite increase neutrophils in the total lung compared with wild-type mice

• however, mice respond normally to challenge with heat-killed P. aeruginosa and neutrophil killing in vitro is normal

increased susceptibility to bacterial infection induced morbidity/mortality ( J:194295 )

• in mice challenged with Pseudomonas aeruginosa

homeostasis/metabolism

increased circulating alanine transaminase level ( J:194295 )

• in mice challenged with Pseudomonas aeruginosa

decreased body temperature ( J:194295 )

• in mice challenged with Pseudomonas aeruginosa

abnormal cytokine level ( J:194295 )

increased circulating interleukin-1 alpha level ( J:194295 )

• in mice challenged with Pseudomonas aeruginosa

increased circulating interleukin-10 level ( J:194295 )

• in mice challenged with Pseudomonas aeruginosa

increased circulating interleukin-6 level ( J:194295 )

• in mice challenged with Pseudomonas aeruginosa

increased circulating tumor necrosis factor level ( J:194295 )

• in mice challenged with Pseudomonas aeruginosa

abnormal chemokine level ( J:194295 )

• mice challenged with Pseudomonas aeruginosa exhibit increased chemokine levels in the bronchoalveaolar lavage fluid and lung homogenate compared with wild-type mice

abnormal circulating chemokine level ( J:194295 )

• mice challenged with Pseudomonas aeruginosa exhibit increased serum chemokine levels compared with wild-type mice

cellular

impaired neutrophil chemotaxis ( J:194295 )

• mice challenged with Pseudomonas aeruginosa exhibit impaired neutrophil migration into airways compared with cells from wild-type mice

• neutrophils exhibit impaired transepithelial migration compared with wild-type cells

• however, neutrophils exhibit normal in vitro chemokine-induced migration and transendothelial migration

hematopoietic system

impaired neutrophil chemotaxis ( J:194295 )

• mice challenged with Pseudomonas aeruginosa exhibit impaired neutrophil migration into airways compared with cells from wild-type mice

• neutrophils exhibit impaired transepithelial migration compared with wild-type cells

• however, neutrophils exhibit normal in vitro chemokine-induced migration and transendothelial migration