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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wwtr1tm1Hmc
targeted mutation 1, Helen McNeill
MGI:5486299
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Wwtr1tm1Hmc/Wwtr1tm1Hmc
Yap1tm1Hmc/Yap1tm1Hmc
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ 		involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl MGI:5486304
cn2
 		Wwtr1tm1Hmc/Wwtr1tm1Hmc
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ 		involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5486303


Genotype
MGI:5486304
cn1
Allelic
Composition		 Wwtr1tm1Hmc/Wwtr1tm1Hmc
Yap1tm1Hmc/Yap1tm1Hmc
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic
Background		 involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six2tm1(tTA,tetO-EGFP/cre)Amc mutation (0 available); any Six2 mutation (16 available)
Wwtr1tm1Hmc mutation (0 available); any Wwtr1 mutation (26 available)
Yap1tm1Hmc mutation (0 available); any Yap1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
kidney cyst ( J:195266 )
• some of the few proximal tubules present are cystic
abnormal kidney development ( J:195266 )
• developmental defects are similar to mutants wild-type for Wwtr1

growth/size/body
kidney cyst ( J:195266 )
• some of the few proximal tubules present are cystic




Genotype
MGI:5486303
cn2
Allelic
Composition		 Wwtr1tm1Hmc/Wwtr1tm1Hmc
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic
Background		 involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six2tm1(tTA,tetO-EGFP/cre)Amc mutation (0 available); any Six2 mutation (16 available)
Wwtr1tm1Hmc mutation (0 available); any Wwtr1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Nephrogenesis abnormalities in Wwtr1tm1Hmc/Wwtr1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+, Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ and double mutant mice

renal/urinary system
kidney hemorrhage ( J:195266 )
• spotty hemorrhages are seen at P0
kidney cyst ( J:195266 )
• highly cystic tubules in the cortex at P0

cardiovascular system
kidney hemorrhage ( J:195266 )
• spotty hemorrhages are seen at P0

growth/size/body
kidney cyst ( J:195266 )
• highly cystic tubules in the cortex at P0




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory