Analysis Tools
mortality/aging
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• mice die 1-2 weeks after macroscopic changes appear (ie. domed skulls); life expectancy of such mutants is 58 days; mice that do not show this phenotype survive at least 12 months and are fertile
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skeleton
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• 47% of mice show dome shaped skulls by about postnatal day 50
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craniofacial
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• 47% of mice show dome shaped skulls by about postnatal day 50
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behavior/neurological
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• mutants spend less time in the center in open-field tests, suggesting increased anxiogenic-like behavior
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• in a novel open-field test, mutants with dome-shaped heads show significantly increased locomotion (likely due to the novelty aspect), as mutants appear lethargic in the home cages
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nervous system
hydrocephaly
(
J:195054
)
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• 47% of mice
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• prominent, varying mild to severe
• in most severe cases, medial structures between ventricles are deformed and compressed, as represented by vertically relocated hippocampi
• ventricular dilation might be result of obstruction of interventricular connections, increased CSF production by ependymal cells of the choroid plexus, or decreased CSF resorption by arachnoid villi
• other ventricles do not show enlargement
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• cortex surrounding lateral ventricles is markedly thinner than in controls
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