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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cxcl12tm1.1Sjm
targeted mutation 1.1, Sean J Morrison
MGI:5486672
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Ndor1Tg(UBC-cre/ERT2)1Ejb/? 		involves: 129S/SvEv * C57BL/6 MGI:5488603
cn2
 		Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Tg(Tek-cre)12Flv/? 		involves: C3H * C57BL/6 MGI:5488609
cn3
 		Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Leprtm2(cre)Rck/Lepr+ 		involves: C57BL/6 MGI:5488610
cn4
 		Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Commd10Tg(Vav1-icre)A2Kio/? 		involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:5488604
cn5
 		Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Tg(Col1a1-cre)2Bek/? 		involves: C57BL/6 * CD-1 MGI:5488611
cn6
 		Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Tg(Nes-cre)1Kln/? 		involves: C57BL/6 * SJL MGI:5488608
cn7
 		Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Tg(Prrx1-cre)1Cjt/? 		involves: C57BL/6 * SJL/J MGI:5488614


Genotype
MGI:5488603
cn1
Allelic
Composition		 Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Ndor1Tg(UBC-cre/ERT2)1Ejb/?
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation (1 available); any Cxcl12 mutation (25 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased bone marrow cell number ( J:194748 )
• reduced bone marrow cellularity
decreased leukocyte cell number ( J:194748 )
• white blood cell counts are significantly reduced after tamoxifen treatment
decreased hematopoietic stem cell number ( J:194748 )
• reduced numbers of CD150+ CD480- LIN- SCA1+ cKIT+ stem cells

immune system
decreased leukocyte cell number ( J:194748 )
• white blood cell counts are significantly reduced after tamoxifen treatment




Genotype
MGI:5488609
cn2
Allelic
Composition		 Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Tg(Tek-cre)12Flv/?
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation (1 available); any Cxcl12 mutation (25 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell physiology ( J:194748 )
• reduced effectiveness in donor cell reconstitution




Genotype
MGI:5488610
cn3
Allelic
Composition		 Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Leprtm2(cre)Rck/Lepr+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation (1 available); any Cxcl12 mutation (25 available)
Leprtm2(cre)Rck mutation (1 available); any Lepr mutation (122 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic system morphology/development ( J:194748 )
• increased hematopoietic cells and colony forming cells in the blood and spleen




Genotype
MGI:5488604
cn4
Allelic
Composition		 Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Commd10Tg(Vav1-icre)A2Kio/?
Genetic
Background		 involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Cxcl12tm1.1Sjm mutation (1 available); any Cxcl12 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:194748 )
N
• normal cellularity and hematopoietic stem cell frequency
• bone marrow/spleen lineage composition is normal




Genotype
MGI:5488611
cn5
Allelic
Composition		 Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Tg(Col1a1-cre)2Bek/?
Genetic
Background		 involves: C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation (1 available); any Cxcl12 mutation (25 available)
Tg(Col1a1-cre)2Bek mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased bone marrow cell number ( J:194748 )
• reduced CLP and IL7RalphaLMPP cells
abnormal bone marrow cell physiology ( J:194748 )
• effectiveness of donor reconstitution of T and B cells is reduced




Genotype
MGI:5488608
cn6
Allelic
Composition		 Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Tg(Nes-cre)1Kln/?
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation (1 available); any Cxcl12 mutation (25 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:194748 )
N
• hematopoietic stem cells and hematopoietic lineage composition are both normal
• bone marrow/spleen cellularity is normal




Genotype
MGI:5488614
cn7
Allelic
Composition		 Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Tg(Prrx1-cre)1Cjt/?
Genetic
Background		 involves: C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation (1 available); any Cxcl12 mutation (25 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:194748 )
• fewer B lineage progenitors
decreased bone marrow cell number ( J:194748 )
• significant reduction in bone marrow cellularity
• reduced frequency of hematopoietic stem cells, CLP and IL7RalphaLMPP cells

immune system
abnormal B cell differentiation ( J:194748 )
• fewer B lineage progenitors




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory