Phenotypes associated with this allele

• Allele Symbol: Tph2^tm1Dmkh
• Allele Name: targeted mutation 1, Donald M Kuhn
• Allele ID: MGI:5487385
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tph2^tm1Dmkh/Tph2^tm1Dmkh	involves: C57BL/6	MGI:5487389

Genotype
MGI:5487389

hm1

• Allelic Composition: Tph2^tm1Dmkh/Tph2^tm1Dmkh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased core body temperature ( J:196205 )

• slightly

decreased serotonin level ( J:196205 )

• absent in the mesencephalic tegmentum, striatum, hippocampus, prefrontal cortex, hypothalamus and cerebellum

• however, serum levels are normal

nervous system

nervous system phenotype ( J:196205 )

N • mice exhibit normal methamphetamine-induced toxicity in the striatal dopamine nerve endings