Phenotypes associated with this allele

• Allele Symbol: Pex11a^tm1Itl
• Allele Name: targeted mutation 1, inGenious Targeting Laboratory
• Allele ID: MGI:5487452
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pex11a^tm1Itl/Pex11a^tm1Itl	C57BL/6-Pex11a^tm1Itl	MGI:5487453

Genotype
MGI:5487453

hm1

• Allelic Composition: Pex11a^tm1Itl/Pex11a^tm1Itl
• Genetic Background: C57BL/6-Pex11a^tm1Itl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:195940 )

N • mice exhibit normal glucose tolerance

increased circulating ketone body level ( J:195940 )

• in fasted mice after 12, but not 24, hours

increased circulating free fatty acids level ( J:195940 )

• in fasted mice after 24 hours

abnormal circulating triglyceride level ( J:195940 )

• tyloxapol-treated mice exhibit a lower rate of increase in plasma triglyceride levels compared with wild-type mice

increased liver triglyceride level ( J:195940 )

• in mice fed a normal or high fat diet

liver/biliary system

increased liver triglyceride level ( J:195940 )

• in mice fed a normal or high fat diet

abnormal hepatocyte morphology ( J:195940 )

• fewer and smaller peroxisomes in the liver with impaired elongation and proliferation and fewer effective peroxisomes

hepatic steatosis ( J:195940 )

• after 30 weeks on a normal diet

• after 12 weeks on a high fat diet

• fasted mice fed a high fat diet exhibit numerous lipid droplets compared with wild-type mice

growth/size/body

increased body weight ( J:195940 )

• under a normal diet or a high fat diet

obese ( J:195940 )

• under a normal diet

cellular

abnormal cell morphology ( J:195940 )

• fewer and smaller peroxisomes in the liver with impaired elongation and proliferation and fewer effective peroxisomes