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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc4a2tm2Ges
targeted mutation 2, Gary E Shull
MGI:5487545
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Slc4a2tm2Ges/Slc4a2tm2Ges
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:5487549
cn2
 		Slc4a2tm2Ges/Slc4a2tm2Ges
Ctsktm1(cre)Ska/Ctsk+ 		involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5487547


Genotype
MGI:5487549
cn1
Allelic
Composition		 Slc4a2tm2Ges/Slc4a2tm2Ges
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc4a2tm2Ges mutation (0 available); any Slc4a2 mutation (53 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increased bone mass in polyI:C treated Slc4a2tm2Ges/Slc4a2tm2Ges Tg(Mx1-cre)1Cgn/0 mice

skeleton
abnormal osteoclast morphology ( J:193823 )
• enlarged following polyI:C treatment
abnormal osteoclast physiology ( J:193823 )
• impaired attachment to bone surfaces following polyI:C treatment
• abnormal spreading and reduced calpain activity in vitro following polyI:C treatment
increased bone mass ( J:193823 )
• following polyI:C treatment

immune system
abnormal osteoclast morphology ( J:193823 )
• enlarged following polyI:C treatment
abnormal osteoclast physiology ( J:193823 )
• impaired attachment to bone surfaces following polyI:C treatment
• abnormal spreading and reduced calpain activity in vitro following polyI:C treatment

hematopoietic system
abnormal osteoclast morphology ( J:193823 )
• enlarged following polyI:C treatment
abnormal osteoclast physiology ( J:193823 )
• impaired attachment to bone surfaces following polyI:C treatment
• abnormal spreading and reduced calpain activity in vitro following polyI:C treatment




Genotype
MGI:5487547
cn2
Allelic
Composition		 Slc4a2tm2Ges/Slc4a2tm2Ges
Ctsktm1(cre)Ska/Ctsk+
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsktm1(cre)Ska mutation (0 available); any Ctsk mutation (31 available)
Slc4a2tm2Ges mutation (0 available); any Slc4a2 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast morphology ( J:193823 )
• partial decrease in spread osteoclast like cells in vitro
abnormal osteoclast physiology ( J:193823 )
• activity of osteoclast like cells is reduced in vitro
abnormal long bone morphology ( J:193823 )
• clubbing of the long bones with decreased marrow space
abnormal long bone metaphysis morphology ( J:193823 )
• cartilage remnants from the growth plate are found in the metaphysis a pathological feature of osteopetrosis
abnormal bone marrow cavity morphology ( J:193823 )
• decreased marrow space
abnormal trabecular bone morphology ( J:193823 )
• trabecular spacing is reduced
increased trabecular bone volume ( J:193823 )
• at 3 and 8 weeks of age

hematopoietic system
abnormal osteoclast morphology ( J:193823 )
• partial decrease in spread osteoclast like cells in vitro
abnormal osteoclast physiology ( J:193823 )
• activity of osteoclast like cells is reduced in vitro

immune system
abnormal osteoclast morphology ( J:193823 )
• partial decrease in spread osteoclast like cells in vitro
abnormal osteoclast physiology ( J:193823 )
• activity of osteoclast like cells is reduced in vitro




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory