Phenotypes associated with this allele

• Allele Symbol: Ubr4^tm1.1Ytkw
• Allele Name: targeted mutation 1.1, Yong Tae Kwon
• Allele ID: MGI:5487648
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ubr4^tm1.1Ytkw/Ubr4^tm1.1Ytkw	involves: 129P2/OlaHsd	MGI:5487653

Genotype
MGI:5487653

hm1

• Allelic Composition: Ubr4^tm1.1Ytkw/Ubr4^tm1.1Ytkw
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:196073 )

• no live embryos are recovered at E11.5

embryo

abnormal vitelline vasculature morphology ( J:196073 )

• defective vascular development

• the vascular network rapidly loses integrity between E8.5 and E9.5

embryonic growth arrest ( J:196073 )

• embryos recovered at E9.0 - E9.5 are arrested at the 14- to 18-somite stage

pale yolk sac ( J:196073 )

• becomes pale by E9.5

abnormal vitelline vascular remodeling ( J:196073 )

• expression analysis indicates vascular development arrests during remodeling of the primary capillary plexus

cellular

abnormal autophagy ( J:196073 )

• expression analysis indicates misregulation of autophagic induction and flux in MEFs

cardiovascular system

abnormal vitelline vasculature morphology ( J:196073 )

• defective vascular development

• the vascular network rapidly loses integrity between E8.5 and E9.5

homeostasis/metabolism

abnormal autophagy ( J:196073 )

• expression analysis indicates misregulation of autophagic induction and flux in MEFs