Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pgrtm1.1(cre)Shah targeted mutation 1.1, Nirao M Shah MGI:5487679 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice injected with an adenovirus expressing a cre-dependent GCaMP6s exhibit no response to a first or second intruder swabbed with the Vmn2r53-activating urine fraction unlike wild-type mice
• however, mice exhibit a normal response to female and castrated male urine or mice, and injection of clozapine N-oxide (selective agonist of hM4D(Gi)) restores aggressiveness
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice injected with an adenovirus expressing a cre-dependent GCaMP6s exhibit no response to a second intruder swabbed with the Vmn2r53-activating urine fraction unlike wild-type mice
• however, mice exhibit a normal response to the first intruder, and injection of clozapine N-oxide (selective agonist of hM4D(Gi)) restores aggressiveness
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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