Analysis Tools
behavior/neurological
| N |
• untreated mice exhibit normal behavior in SHIRPA analysis
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• mice treated with imipramine exhibit pronounced shoulder hunching accompanied by body tremors and spasm compared with wild-type mice that appear sedated
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homeostasis/metabolism
| N |
• untreated mice exhibit normal blood plasma biochemical analysis
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• mice treated with imipramine exhibit a 2.7-fold increase in serum imipramine levels, an increased imipramine in the kidney, failure to produce imipramine N-oxide and desipramine in the brain compared with wild-type mice
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