Phenotypes associated with this allele

• Allele Symbol: Del(1Fmo4-Fmo2)1Eshe
• Allele Name: deletion, Chr 1, Elizabeth A Shephard 1
• Allele ID: MGI:5487815
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(1Fmo4-Fmo2)1Eshe/Del(1Fmo4-Fmo2)1Eshe	B6.129P2-Del(1Fmo4-Fmo2)1Eshe	MGI:5487818
ht2	Del(1Fmo4-Fmo2)1Eshe/+	B6.129P2-Del(1Fmo4-Fmo2)1Eshe	MGI:5487820

Genotype
MGI:5487818

hm1

• Allelic Composition: Del(1Fmo4-Fmo2)1Eshe/Del(1Fmo4-Fmo2)1Eshe
• Genetic Background: B6.129P2-Del(1Fmo4-Fmo2)1Eshe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196270 )

N • untreated mice exhibit normal behavior in SHIRPA analysis

enhanced behavioral response to anesthetic ( J:196270 )

• mice treated with imipramine exhibit pronounced shoulder hunching accompanied by body tremors and spasm compared with wild-type mice that appear sedated

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196270 )

N • untreated mice exhibit normal blood plasma biochemical analysis

abnormal physiological response to xenobiotic ( J:196270 )

• mice treated with imipramine exhibit a 2.7-fold increase in serum imipramine levels, an increased imipramine in the kidney, failure to produce imipramine N-oxide and desipramine in the brain compared with wild-type mice

Genotype
MGI:5487820

ht2

• Allelic Composition: Del(1Fmo4-Fmo2)1Eshe/+
• Genetic Background: B6.129P2-Del(1Fmo4-Fmo2)1Eshe

behavior/neurological

enhanced behavioral response to anesthetic ( J:196270 )

• mice treated with imipramine exhibit an intermediate response compared with wild-type and homozygous mice