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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rock2tm2Liao
targeted mutation 2, James K Liao
MGI:5488746
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rock2tm2Liao/Rock2tm2Liao
Tg(Myh6-cre)2182Mds/? 		involves: 129/Sv * C57BL/6 MGI:5491820


Genotype
MGI:5491820
cn1
Allelic
Composition		 Rock2tm2Liao/Rock2tm2Liao
Tg(Myh6-cre)2182Mds/?
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock2tm2Liao mutation (0 available); any Rock2 mutation (60 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:196433 )
N
• no anatomical or functional cardiac abnormalities before 25 weeks of age
• increase in systolic blood pressure in response to Ang II is similar to controls
abnormal heart morphology ( J:196433 )
• less fibrosis than controls from Ang II infusion
abnormal heart size ( J:196433 )
• less cardiac hypertrophy than controls from Ang II infusion
• less cardiac hypertrophy due to trans aortic constriction




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory