All Phenotypes Rock2<tm2Liao> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rock2^tm2Liao
targeted mutation 2, James K Liao
MGI:5488746

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rock2^tm2Liao/Rock2^tm2Liao Tg(Myh6-cre)2182Mds/?	involves: 129/Sv * C57BL/6	MGI:5491820

Allelic Composition	Rock2^tm2Liao/Rock2^tm2Liao Tg(Myh6-cre)2182Mds/?
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock2^tm2Liao mutation (0 available); any Rock2 mutation (60 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:196433 )

N	• no anatomical or functional cardiac abnormalities before 25 weeks of age • increase in systolic blood pressure in response to Ang II is similar to controls

abnormal heart morphology ( J:196433 )

• less fibrosis than controls from Ang II infusion

abnormal heart size ( J:196433 )

• less cardiac hypertrophy than controls from Ang II infusion

• less cardiac hypertrophy due to trans aortic constriction

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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