Phenotypes associated with this allele

• Allele Symbol: Has2^tm1.2Chg
• Allele Name: targeted mutation 1.2, Chin Chiang
• Allele ID: MGI:5489765
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Has2^tm1.1Chg/Has2^tm1.2Chg Tg(Hoxb6-cre)#Mku/0	involves: 129 * Black Swiss * C57BL/6 * FVB/N * SJL	MGI:5489766

Genotype
MGI:5489766

cn1

• Allelic Composition: Has2^tm1.1Chg/Has2^tm1.2Chg; Tg(Hoxb6-cre)#Mku/0
• Genetic Background: involves: 129 * Black Swiss * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal cartilage morphology ( J:194283 )

• severe cartilage reduction at P0

abnormal cartilage development ( J:194283 )

abnormal chondrocyte differentiation ( J:194283 )

• reduced chondrocyte differentiation

abnormal joint morphology ( J:194283 )

• joint positioning defects at P0 indicated by prominent changes in phalangeal cartilage nodule organization

• the interphalangeal joints are shifted perpendicularly at P0

• ectopic joints along the digit rays

limbs/digits/tail

abnormal limb mesenchyme morphology ( J:194283 )

• impaired phalangeal mesenchymal condensation

• however, mesenchyme proliferation is normal

abnormal digit morphology ( J:194283 )

• longitudinally oriented cavities that split proximal and medial phalanges

• digit defect in the forelimb is restricted to the posterior digits

embryo

abnormal limb mesenchyme morphology ( J:194283 )

• impaired phalangeal mesenchymal condensation

• however, mesenchyme proliferation is normal