Phenotypes associated with this allele

• Allele Symbol: Egr3^tm2.1Wgt
• Allele Name: targeted mutation 2.1, Warrren G Tourtellotte
• Allele ID: MGI:5489891
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Egr3^tm1Jmi/Egr3^tm2.1Wgt Tg(DBH-cre,-taulacZ)1Wgt/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5489937

Genotype
MGI:5489937

cn1

• Allelic Composition: Egr3^tm1Jmi/Egr3^tm2.1Wgt; Tg(DBH-cre,-taulacZ)1Wgt/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

superior cervical ganglion degeneration ( J:196371 )

• conditional mutants display neuron loss in the superior cervical ganglion (SCG), similar to that described in germline Egr3 mutants

abnormal sympathetic neuron innervation pattern ( J:196371 )

• peripheral sympathetic target tissue innervation is abnormal in conditional mutants, closely resembling defects described in germline Egr3 mutants; innervation to the heart, spleen, kidney, and pineal gland is reduced

vision/eye

blepharoptosis ( J:196371 )

• sympathetic nervous system abnormalities like blepharoptosis are evident in conditional mutants, similar to defects described in germline Egr3 mutants

behavior/neurological

behavior/neurological phenotype ( J:196371 )

N • mice lack the scoliosis and gait ataxia observed in Egr3 germline mutants