Phenotypes associated with this allele

• Allele Symbol: Tgfb1^tm1Mki
• Allele Name: targeted mutation 1, Masao Kakoki
• Allele ID: MGI:5490035
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgfb1^tm1Mki/Tgfb1^tm1Mki	C57BL/6-Tgfb1^tm1Mki	MGI:5490037

Genotype
MGI:5490037

hm1

• Allelic Composition: Tgfb1^tm1Mki/Tgfb1^tm1Mki
• Genetic Background: C57BL/6-Tgfb1^tm1Mki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hypervolemia ( J:194237 )

• plasma volume is increased by approximately 50% compared to wild-type controls

• however, plasma osmolarity and sodium and chloride concentrations are similar to controls

decreased heart rate ( J:194237 )

• substantially lower pulse rate

increased systemic arterial systolic blood pressure ( J:194237 )

• markedly increased

homeostasis/metabolism

abnormal homeostasis ( J:194237 )

• increase in electrolyte levels in hair

• treatment with spironolactone or amiloride decreases blood pressure and plasma volume and increases urinary sodium levels

increased circulating corticosterone level ( J:194237 )

• at 12 weeks of age

increased circulating aldosterone level ( J:194237 )

• about 200% of wild-type levels at 12 weeks of age

decreased circulating potassium level ( J:194237 )

• at 12 weeks of age

decreased circulating angiotensinogen level ( J:194237 )

• approximately 30% of wild-type levels

decreased circulating renin level ( J:194237 )

increased body temperature ( J:194237 )

• 1.1 ^oC increase compared to wild-type mice

abnormal fluid regulation ( J:194237 )

• water condensation in metabolic cages suggests water loss via extrarenal mechanisms

decreased urine chloride ion level ( J:194237 )

abnormal urine potassium level ( J:194237 )

decreased urine sodium level ( J:194237 )

decreased urine osmolality ( J:194237 )

• osmolarity is less than one fifth that of wild-type controls

increased basal metabolism ( J:194237 )

• heat production is 1.3 times that of wild-type mice

behavior/neurological

increased fluid intake ( J:194237 )

• water intake is almost twice that of wild-type controls

hyperactivity ( J:194237 )

• twice that of wild-type controls

endocrine/exocrine glands

enlarged adrenal glands ( J:194237 )

• adrenal weight normalized to body weight is doubled compared to wild-type littermates

renal/urinary system

decreased urine chloride ion level ( J:194237 )

abnormal urine potassium level ( J:194237 )

decreased urine sodium level ( J:194237 )

decreased urine osmolality ( J:194237 )

• osmolarity is less than one fifth that of wild-type controls

oliguria ( J:194237 )

• urine volume is less than one fifth that of wild-type controls