About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ntrk2tm2.1Ddg
targeted mutation 2.1, David D Ginty
MGI:5490140
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ntrk2tm2.1Ddg/Ntrk2tm2.1Ddg involves: 129P2/OlaHsd MGI:5617024
hm2
Ntrk2tm2.1Ddg/Ntrk2tm2.1Ddg involves: 129S6/SvEvTac MGI:5617032
hm3
Ntrk2tm2.1Ddg/Ntrk2tm2.1Ddg involves: 129S6/SvEvTac * C57BL/6 MGI:5490142


Genotype
MGI:5617024
hm1
Allelic
Composition
Ntrk2tm2.1Ddg/Ntrk2tm2.1Ddg
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm2.1Ddg mutation (1 available); any Ntrk2 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at E12, male and female mice exhibit impaired initial axonal projections in the mammary gland compared with wild-type mice
• at E13, female mice exhibit reduced sensory neurons innervation of the mammary gland rudiments compared with wild-type mice

endocrine/exocrine glands
• at E12, male and female mice exhibit impaired initial axonal projections in the mammary gland compared with wild-type mice
• at E13, female mice exhibit reduced sensory neurons innervation of the mammary gland rudiments compared with wild-type mice

integument
• at E12, male and female mice exhibit impaired initial axonal projections in the mammary gland compared with wild-type mice
• at E13, female mice exhibit reduced sensory neurons innervation of the mammary gland rudiments compared with wild-type mice




Genotype
MGI:5617032
hm2
Allelic
Composition
Ntrk2tm2.1Ddg/Ntrk2tm2.1Ddg
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm2.1Ddg mutation (1 available); any Ntrk2 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are not viable




Genotype
MGI:5490142
hm3
Allelic
Composition
Ntrk2tm2.1Ddg/Ntrk2tm2.1Ddg
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm2.1Ddg mutation (1 available); any Ntrk2 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory