All Phenotypes Ampd2<tm1Tm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ampd2^tm1Tm
targeted mutation 1, Takayuki Morisaki
MGI:5490144

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ampd2^tm1Tm/Ampd2^tm1Tm	B6.129S2-Ampd2^tm1Tm	MGI:5490220
hm2	Ampd2^tm1Tm/Ampd2^tm1Tm	involves: 129S2/SvPas	MGI:5529925
cx3	Ampd2^tm1Tm/Ampd2^tm1Tm Ampd3^{tm2a(KOMP)Wtsi}/Ampd3^{tm2a(KOMP)Wtsi}	involves: 129S2/SvPas * C57BL/6N	MGI:5559171

Allelic Composition	Ampd2^tm1Tm/Ampd2^tm1Tm
Genetic Background	B6.129S2-Ampd2^tm1Tm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ampd2^tm1Tm mutation (1 available); any Ampd2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased urine protein level ( J:196782 )

• at 3 weeks of age with highest levels at 6 weeks of age

podocyte foot process effacement ( J:196782 )

• at 8, 12 and 32 weeks

abnormal renal tubule morphology ( J:196782 )

• at 12 and 24 weeks, tubules are filled with protein casts

• however, there is no obvious change in the glomerulus

homeostasis/metabolism

increased urine protein level ( J:196782 )

• at 3 weeks of age with highest levels at 6 weeks of age

Allelic Composition	Ampd2^tm1Tm/Ampd2^tm1Tm
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ampd2^tm1Tm mutation (1 available); any Ampd2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:201211 )

N	• lung inflammation after hind limb ischemia and reperfusion is similar to controls

Allelic Composition	Ampd2^tm1Tm/Ampd2^tm1Tm Ampd3^{tm2a(KOMP)Wtsi}/Ampd3^{tm2a(KOMP)Wtsi}
Genetic Background	involves: 129S2/SvPas * C57BL/6N
Cell Lines	EPD0043_3_B02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ampd2^tm1Tm mutation (1 available); any Ampd2 mutation (45 available)
Ampd3^{tm2a(KOMP)Wtsi} mutation (2 available); any Ampd3 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:200072 )

• lifespan is limited to 2 to 3 weeks

nervous system

neurodegeneration ( J:200072 )

• after P14, mostly affecting the CA3 pyramidal neurons in the hippocampus with some pyknotic cells in the cortex and cerebellum

behavior/neurological

abnormal gait ( J:200072 )

growth/size/body

decreased body weight ( J:200072 )

• slight

homeostasis/metabolism

abnormal nucleotide metabolism ( J:200072 )

• increased ATP nucleotide levels in the brain at 2 weeks

• decreased GTP nucleotide levels in the brain at 2 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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