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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adgrf5tm1.2Bstc
targeted mutation 1.2, Brad St Croix
MGI:5490511
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adgrf5tm1.2Bstc/Adgrf5tm1.2Bstc involves: 129S4/SvJae * C57BL/6J MGI:5490532
cn2
 		Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Tg(Tek-cre)12Flv/0 		involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J MGI:5490533
cn3
 		Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J MGI:5490536
cn4
 		Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Tg(Sftpc-cre)1Blh/0 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2 MGI:5490535
cn5
 		Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: 129S4/SvJae * C57BL/6J * C57BL/10 * CBA/Ca MGI:5490534


Genotype
MGI:5490532
hm1
Allelic
Composition		 Adgrf5tm1.2Bstc/Adgrf5tm1.2Bstc
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrf5tm1.2Bstc mutation (0 available); any Adgrf5 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

respiratory system
increased lung cholesterol level ( J:196943 )
• 13-fold increase in the bronchoalveolar lavage fluid
• however, serum levels are normal
pulmonary alveolar proteinosis ( J:196943 )
• with milky bronchoalveolar lavage fluid
increased alveolar lamellar body number ( J:196943 )
• of alveolar type II cells
respiratory distress ( J:196943 )
• by 4 months of age
abnormal surfactant physiology ( J:196943 )
• surfactant uptake into alveolar type II cells is impaired
increased surfactant secretion ( J:196943 )
• increased surfactant protein A by 2 weeks of age and increasing with time
• increased surfactant protein A, B, C and D in whole lung lysate

homeostasis/metabolism
increased lung cholesterol level ( J:196943 )
• 13-fold increase in the bronchoalveolar lavage fluid
• however, serum levels are normal
abnormal phospholipid level ( J:196943 )
• 8-fold increase of phosphatidylcholine in the bronchoalveolar lavage fluid
pulmonary alveolar proteinosis ( J:196943 )
• with milky bronchoalveolar lavage fluid

growth/size/body
decreased body weight ( J:196943 )
• by 14 months of age

cellular
increased macrophage derived foam cell number ( J:196943 )
• of enlarged foamy macrophages with surfactant-laden phagosomes and cholesterol clefts in the bronchoalveolar lavage fluid

immune system
increased macrophage derived foam cell number ( J:196943 )
• of enlarged foamy macrophages with surfactant-laden phagosomes and cholesterol clefts in the bronchoalveolar lavage fluid

hematopoietic system
increased macrophage derived foam cell number ( J:196943 )
• of enlarged foamy macrophages with surfactant-laden phagosomes and cholesterol clefts in the bronchoalveolar lavage fluid




Genotype
MGI:5490533
cn2
Allelic
Composition		 Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrf5tm1.1Bstc mutation (1 available); any Adgrf5 mutation (74 available)
Adgrf5tm1.2Bstc mutation (0 available); any Adgrf5 mutation (74 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:196943 )
N
• mice exhibit normal surfactant homeostasis in the lung




Genotype
MGI:5490536
cn3
Allelic
Composition		 Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrf5tm1.1Bstc mutation (1 available); any Adgrf5 mutation (74 available)
Adgrf5tm1.2Bstc mutation (0 available); any Adgrf5 mutation (74 available)
Tg(SFTPC-rtTA)5Jaw mutation (4 available)
Tg(tetO-cre)1Jaw mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid level ( J:196943 )
• increased phosphatidylcholine in the bronchoalveolar lavage fluid of doxycycline-treated mice
increased cholesterol level ( J:196943 )
• in the bronchoalveolar lavage fluid of doxycycline-treated mice

respiratory system
increased surfactant secretion ( J:196943 )
• increased surfactant protein A, B, C and D in the whole lung lysate of doxycycline-treated mice




Genotype
MGI:5490535
cn4
Allelic
Composition		 Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Tg(Sftpc-cre)1Blh/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrf5tm1.1Bstc mutation (1 available); any Adgrf5 mutation (74 available)
Adgrf5tm1.2Bstc mutation (0 available); any Adgrf5 mutation (74 available)
Tg(Sftpc-cre)1Blh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
pulmonary alveolar proteinosis ( J:196943 )
• as in Gpr116tm1.2Bstc homozygotes

homeostasis/metabolism
pulmonary alveolar proteinosis ( J:196943 )
• as in Gpr116tm1.2Bstc homozygotes




Genotype
MGI:5490534
cn5
Allelic
Composition		 Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrf5tm1.1Bstc mutation (1 available); any Adgrf5 mutation (74 available)
Adgrf5tm1.2Bstc mutation (0 available); any Adgrf5 mutation (74 available)
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:196943 )
N
• mice exhibit normal surfactant homeostasis in the lung




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory