Phenotypes associated with this allele

• Allele Symbol: Siglece^tm1Croc
• Allele Name: targeted mutation 1, Paul Crocker
• Allele ID: MGI:5490544
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Siglece^tm1Croc/Siglece^tm1Croc	B6.129P2-Siglece^tm1Croc	MGI:5490548

Genotype
MGI:5490548

hm1

• Allelic Composition: Siglece^tm1Croc/Siglece^tm1Croc
• Genetic Background: B6.129P2-Siglece^tm1Croc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal neutrophil physiology ( J:195429 )

• during LPS-induced acute lung airway inflammation, mice exhibit increased neutrophil and macrophage recruitment compared with wild-type mice

• mice exhibit increased neutrophil recruitment in response to intranasal zymosan compared with wild-type mice

• however, blockage of CD11B reverses increased recruitment in LPS-treated mice

• however, neutrophil recruitment is normal in thioglycollate-induced peritonitis and acute inflammation in an air pouch model induced by TNFa or Staphylococcus aureus

abnormal macrophage physiology ( J:195429 )

• during LPS-induced acute lung airway inflammation, mice exhibit increased neutrophil and macrophage recruitment compared with wild-type mice

hematopoietic system

abnormal neutrophil physiology ( J:195429 )

• during LPS-induced acute lung airway inflammation, mice exhibit increased neutrophil and macrophage recruitment compared with wild-type mice

• mice exhibit increased neutrophil recruitment in response to intranasal zymosan compared with wild-type mice

• however, blockage of CD11B reverses increased recruitment in LPS-treated mice

• however, neutrophil recruitment is normal in thioglycollate-induced peritonitis and acute inflammation in an air pouch model induced by TNFa or Staphylococcus aureus

abnormal macrophage physiology ( J:195429 )

• during LPS-induced acute lung airway inflammation, mice exhibit increased neutrophil and macrophage recruitment compared with wild-type mice