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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nrltm1Jcco
targeted mutation 1, Joseph C Corbo
MGI:5490567
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nrltm1Jcco/Nrltm1Jcco involves: C57BL/6 * CBA MGI:5490588
cn2
 		Nrltm1Jcco/Nrltm1Jcco
Rhotm1Jlem/Rhotm1Jlem
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:5490597
cn3
 		Nrltm1Jcco/Nrltm1Jcco
Tg(CAG-cre/Esr1*)5Amc/0 		involves: C57BL/6 * CBA MGI:5490590


Genotype
MGI:5490588
hm1
Allelic
Composition		 Nrltm1Jcco/Nrltm1Jcco
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrltm1Jcco mutation (1 available); any Nrl mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:193697 )
N
• normal retinal development and function




Genotype
MGI:5490597
cn2
Allelic
Composition		 Nrltm1Jcco/Nrltm1Jcco
Rhotm1Jlem/Rhotm1Jlem
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrltm1Jcco mutation (1 available); any Nrl mutation (19 available)
Rhotm1Jlem mutation (6 available); any Rho mutation (51 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Rod reprogramming prevents retinal degeneration in tamoxifen treated Rhotm1Jlem/Rhotm1Jlem Nrltm1Jcco/Nrltm1Jcco Tg(CAG-cre/Esr1*)5Amc/0 mice

vision/eye
vision/eye phenotype ( J:193697 )
N
• photoreceptor death observed in Rhotm1Jlem homozygotes is prevented in tamoxifen-treated mice with preservation of rod cell bodies and inner segments and intact photopic b-wave over a wide range of flash intensities




Genotype
MGI:5490590
cn3
Allelic
Composition		 Nrltm1Jcco/Nrltm1Jcco
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrltm1Jcco mutation (1 available); any Nrl mutation (19 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Adult rods are reprogrammed into cone-like cells in Nrltm1Jcco/Nrltm1Jcco Tg(CAG-cre/Esr1*)5Amc/0 mice

vision/eye
abnormal retina photoreceptor morphology ( J:193697 )
• tamoxifen-treated mice exhibit reprogramming of rods into cone-like cells
abnormal eye physiology ( J:193697 )
• in response to a series of light stimuli, reprogrammed retina in tamoxifen-treated mice exhibit lower maximal response amplitudes compared with control mice
• photopigment-bleached reprogrammed retina from tamoxifen-treated mice allowed to dark adapt in the presence of 9-cis-retinol are able to completely recover their photoresponse and largely restore their sensitivity
abnormal rod electrophysiology ( J:193697 )
• decreased scotopic a, but not b, wave amplitude in tamoxifen-treated mice
• like cone cells, dark-adapted reprogrammed rod cells in tamoxifen-treated mice exhibit a 35-fold desensitization and more rapid inactivation of photoresponse

nervous system
abnormal retina photoreceptor morphology ( J:193697 )
• tamoxifen-treated mice exhibit reprogramming of rods into cone-like cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory