Phenotypes associated with this allele

• Allele Symbol: Rgs12^tm1.1Syy
• Allele Name: targeted mutation 1.1, Shuying Yang
• Allele ID: MGI:5490960
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rgs12^tm1.1Syy/Rgs12^tm1.1Syy Tg(Mx1-cre)1Cgn/0	involves: 129 * C57BL/6 * CBA	MGI:5490966

Genotype
MGI:5490966

cn1

• Allelic Composition: Rgs12^tm1.1Syy/Rgs12^tm1.1Syy; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129 * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased osteoclast cell number ( J:194057 )

• few osteoclasts are present in the tibia after polyI:C treatment

• however, osteoblast numbers are similar to control

abnormal bone marrow cavity morphology ( J:194057 )

• percentage of bone area to total marrow space in long bones is 1.9 fold that of controls

increased bone volume ( J:194057 )

• following polyI:C treatment

abnormal trabecular bone morphology ( J:194057 )

• decreased trabecular spacing in the tibia after polyI:C treatment

increased bone trabecula number ( J:194057 )

• following polyI:C treatment

• abundance of bone and cartilage trabeculae following polyI:C treatment

increased trabecular bone thickness ( J:194057 )

• following polyI:C treatment

increased bone mass ( J:194057 )

• following polyI:C treatment

osteopetrosis ( J:194057 )

• following polyI:C treatment

immune system

decreased osteoclast cell number ( J:194057 )

• few osteoclasts are present in the tibia after polyI:C treatment

• however, osteoblast numbers are similar to control

hematopoietic system

decreased osteoclast cell number ( J:194057 )

• few osteoclasts are present in the tibia after polyI:C treatment

• however, osteoblast numbers are similar to control