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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eef1a1tm2Arge
targeted mutation 2, Argiris Efstratiadis
MGI:5491024
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Eef1a1tm2Arge/Eef1a1+
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: C57BL/6 * C57BL/6NTac MGI:5496427
cn2
 		Eef1a1tm2Arge/Eef1a1+
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:5491045


Genotype
MGI:5496427
cn1
Allelic
Composition		 Eef1a1tm2Arge/Eef1a1+
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm2Arge mutation (0 available); any Eef1a1 mutation (60 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (994 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell physiology ( J:196407 )
• leukemia-initiating cells plated in methylcellulose cultures in the presence of tamoxifen exhibit decreased blast colony number and loss of blast colony formation due to increased apoptosis compared with control cells




Genotype
MGI:5491045
cn2
Allelic
Composition		 Eef1a1tm2Arge/Eef1a1+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm2Arge mutation (0 available); any Eef1a1 mutation (60 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased acute lymphoblastic leukemia incidence ( J:197167 )
• T cell acute lymphoblastic leukemia (T-ALL)
• progressive leukemic cells infiltrate the leptomeningeal spaces of the brain

immune system
abnormal double-positive T cell morphology ( J:197167 )
• atypical CD4+CD8+ T cells in the peripheral blood

hematopoietic system
abnormal double-positive T cell morphology ( J:197167 )
• atypical CD4+CD8+ T cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory