Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation
(43 available);
any
Prnp mutation
(148 available)
Tg(Prnp)4053Sbp mutation
(0 available)
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immune system
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• mutants show increased susceptibility to developing scrapie following RML prion inoculation, with an average incubation time of 59 days compared to 138 days in controls and average death of 65 days versus 159 days in controls
• however, scrapie incubation times and time of death in mutants inoculated with RML prions is prolonged by about 10 days compared to single Tg(Prnp)4053Sbp mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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nervous system
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• mice remain free of central nervous system (CNS) dysfunction for more than 600 days of age, however 6 of 20 mutants develop CNS dysfunction between 605 and 815 days of age
• no neuropathic evidence for prion disease is evident
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immune system
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• mutants show increased susceptibility to developing scrapie following RML prion inoculation, with abbreviated incubation times (45 days vs. 138 days in controls) and earlier onset of death (58 days vs. 159 days) than controls
• however, brains of ill mutants inoculated with RML prions show reduced spongiform degeneration and reactive astrocytic gliosis compared to nontransgenic mice
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