Analysis Tools
mortality/aging
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• median lifespan of 85 days
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growth/size/body
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• at 8 weeks of age
• weight gain starts at 7 weeks of age and is more gradual than in mutant mice not carrying the transgene
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nervous system
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• brain weight peaks at 7 weeks (1 week earlier than in controls) then declines
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• brain weight peaks at 7 weeks (1 week earlier than in controls) then declines
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• decrease in the number of ATRX containing foci at 7 weeks of age and only a few foci are detected at 9 weeks of age
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• decrease in the number of ATRX containing foci at 7 weeks of age and only a few foci are detected at 9 weeks of age
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behavior/neurological
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• at all ages tested and severity increases with age
• severity is reduced compared to mutant mice not carrying the transgene
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|
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• at all ages tested and severity increases with age
• severity is reduced compared to mutant mice not carrying the transgene
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integument
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• at 8 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Rett syndrome | DOID:1206 |
OMIM:312750 OMIM:613454 |
J:194039 | |
