Phenotypes associated with this allele

• Allele Symbol: Tg(Plp1-Lmnb1)#Yfu
• Allele Name: transgene insertion, Ying-Hui Fu
• Allele ID: MGI:5491149
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Plp1-Lmnb1)#Yfu/0	involves: FVB	MGI:5491207

Genotype
MGI:5491207

tg1

• Allelic Composition: Tg(Plp1-Lmnb1)#Yfu/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:197168 )

• mice are moribund at 12 months

nervous system

seizures ( J:197168 )

abnormal myelin sheath morphology ( J:197168 )

axon degeneration ( J:197168 )

demyelination ( J:197168 )

• in some fibers

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:197168 )

• age-dependent motor deficits beginning at 10 months and rapidly progressing to 12 months

impaired coordination ( J:197168 )

• on an accelerating rotarod and balance beam at 12 months

seizures ( J:197168 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
adult-onset autosomal dominant demyelinating leukodystrophy		DOID:0060785	OMIM:169500	J:197168