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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k8tm1Sley
targeted mutation 1, Steven C Ley
MGI:5491226
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Map3k8tm1Sley/Map3k8tm1Sley
Nfkb1tm1Sley/Nfkb1tm1Sley 		involves: 129S4/SvJae MGI:5491300


Genotype
MGI:5491300
cx1
Allelic
Composition		 Map3k8tm1Sley/Map3k8tm1Sley
Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8tm1Sley mutation (0 available); any Map3k8 mutation (41 available)
Nfkb1tm1Sley mutation (0 available); any Nfkb1 mutation (102 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:196528 )
• from bone marrow-derived macrophage stimulated with LPS




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory