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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd244aChip
chip
MGI:5491497
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd244aChip/Cd244aChip C57BL/6J-Cd244aChip MGI:5491506
ht2
 		Cd244aChip/Cd244a+ C57BL/6J-Cd244aChip MGI:5491507


Genotype
MGI:5491506
hm1
Allelic
Composition		 Cd244aChip/Cd244aChip
Genetic
Background		 C57BL/6J-Cd244aChip
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd244aChip mutation (0 available); any Cd244a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell physiology ( J:196519 )
• reduced capacity to recognize and eliminate missing-self targets
• however, antigen-specific targeting and killing are normal
• mice exhibit increased clearance of B16 melanoma tumors

hematopoietic system
abnormal NK cell physiology ( J:196519 )
• reduced capacity to recognize and eliminate missing-self targets
• however, antigen-specific targeting and killing are normal
• mice exhibit increased clearance of B16 melanoma tumors




Genotype
MGI:5491507
ht2
Allelic
Composition		 Cd244aChip/Cd244a+
Genetic
Background		 C57BL/6J-Cd244aChip
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd244aChip mutation (0 available); any Cd244a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell physiology ( J:196519 )
• intermediately reduced capacity to recognize and eliminate missing-self targets
• however, antigen-specific targeting and killing are normal
impaired natural killer cell mediated cytotoxicity ( J:196519 )
• intermediately towards missing-self targets

hematopoietic system
abnormal NK cell physiology ( J:196519 )
• intermediately reduced capacity to recognize and eliminate missing-self targets
• however, antigen-specific targeting and killing are normal
impaired natural killer cell mediated cytotoxicity ( J:196519 )
• intermediately towards missing-self targets




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory