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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lcp2m1Khoe
mutation 1, Kasper Hoebe
MGI:5491498
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lcp2m1Khoe/Lcp2m1Khoe C57BL/6J-Lcp2m1Khoe MGI:5491508


Genotype
MGI:5491508
hm1
Allelic
Composition		 Lcp2m1Khoe/Lcp2m1Khoe
Genetic
Background		 C57BL/6J-Lcp2m1Khoe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcp2m1Khoe mutation (0 available); any Lcp2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell physiology ( J:196519 )
• reduced capacity to recognize and eliminate missing-self targets
• mice exhibit increased clearance of B16 melanoma tumors
• however, antigen-specific targeting and killing are normal

hematopoietic system
abnormal NK cell physiology ( J:196519 )
• reduced capacity to recognize and eliminate missing-self targets
• mice exhibit increased clearance of B16 melanoma tumors
• however, antigen-specific targeting and killing are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory