Analysis Tools
nervous system
microgliosis
(
J:162842
)
|
• dense amyloid deposits are seen in the frontal cortex, but not in other brain areas, at 3-4 months of age
• by 5-7 months of age, an increase in size and numbers of plaques in the frontal cortex is seen and dense amyloid deposits are seen in the subiculum of the hippocampus, thalamus, and olfactory region
• at 9-11 months of age, extensive amyloid deposits are seen in most of the neocortex, hippocampus, thalamus, and cerebellum
• amyloid deposition is seen around blood vessels and in the pial surface, accompanied by astrogliosis and microgliosis
• most plaques have abundant extracellular amyloid fibrils surrounded by dystrophic neurites containing abundant electrodense laminar bodies, vesicles and synapses
• amyloid beta 1-42 is the most abundant species
|
astrocytosis
(
J:162842
)
|
• progressive loss of synaptophysin-immunoreactive presynaptic terminals in the frontal cortex beginning at 3-4 months of age and in the hippocampus beginning at 5-7 months of age
|
hematopoietic system
microgliosis
(
J:162842
)
immune system
microgliosis
(
J:162842
)
homeostasis/metabolism
|
• dense amyloid deposits are seen in the frontal cortex, but not in other brain areas, at 3-4 months of age
• by 5-7 months of age, an increase in size and numbers of plaques in the frontal cortex is seen and dense amyloid deposits are seen in the subiculum of the hippocampus, thalamus, and olfactory region
• at 9-11 months of age, extensive amyloid deposits are seen in most of the neocortex, hippocampus, thalamus, and cerebellum
• amyloid deposition is seen around blood vessels and in the pial surface, accompanied by astrogliosis and microgliosis
• most plaques have abundant extracellular amyloid fibrils surrounded by dystrophic neurites containing abundant electrodense laminar bodies, vesicles and synapses
• amyloid beta 1-42 is the most abundant species
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:162842 | ||
