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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctsktm1.1Rbar
targeted mutation 1.1, Roland Baron
MGI:5492037
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ctsktm1.1Rbar/Ctsktm1.1Rbar Not Specified MGI:5492065
cn2
 		Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Itgam-cre)AJva/0 		involves: C57BL/6 MGI:5492066
cn3
 		Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:5492067
cn4
 		Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: CD-1 MGI:5492068


Genotype
MGI:5492065
hm1
Allelic
Composition		 Ctsktm1.1Rbar/Ctsktm1.1Rbar
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsktm1.1Rbar mutation (0 available); any Ctsk mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:194492 )
N
• mice exhibit normal cancellous, cortical and total bone mineral density




Genotype
MGI:5492066
cn2
Allelic
Composition		 Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Itgam-cre)AJva/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsktm1.1Rbar mutation (0 available); any Ctsk mutation (31 available)
Tg(Itgam-cre)AJva mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increase in cancellous bone mass in Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Mx1-cre)1Cgn/0 and Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Itgam-cre)AJva/0 mice

skeleton
increased bone volume ( J:194492 )
• increased femoral cross-sectional bone volume
increased bone mineralization ( J:194492 )
• increased mineral apposition
increased bone ossification ( J:194492 )
• increased bone formation

immune system

hematopoietic system




Genotype
MGI:5492067
cn3
Allelic
Composition		 Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsktm1.1Rbar mutation (0 available); any Ctsk mutation (31 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increase in cancellous bone mass in Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Mx1-cre)1Cgn/0 and Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Itgam-cre)AJva/0 mice

skeleton
abnormal osteoblast differentiation ( J:194492 )
• CFU-ALP and CFU osteoblasts are increased in pIpC-treated mice compared with controls
• however, the number of CFU fibroblasts is normal
abnormal osteoclast differentiation ( J:194492 )
• in pIpC-treated bone marrow macrophages
abnormal osteoblast physiology ( J:194492 )
• osteoblasts from the long bones of pIpC-treated mice exhibit increased ALP activity and formed more mineralized bone nodules compared with control cells
• however, osteoblast proliferation is normal
increased osteoclast cell number ( J:194492 )
• in pIpC-treated mice
abnormal osteoclast physiology ( J:194492 )
• pIpC-treated mice exhibit reduced resorption pit depths compared with control mice
increased trabecular bone volume ( J:194492 )
• in pIpC-treated mice
increased osteoblast cell number ( J:194492 )
• in pIpC-treated mice
increased bone trabecula number ( J:194492 )
• in pIpC-treated mice
increased trabecular bone connectivity density ( J:194492 )
• in pIpC-treated mice with reduced trabecular separation
increased trabecular bone mass ( J:194492 )
• in pIpC-treated mice

cellular
abnormal osteoblast differentiation ( J:194492 )
• CFU-ALP and CFU osteoblasts are increased in pIpC-treated mice compared with controls
• however, the number of CFU fibroblasts is normal
abnormal osteoclast differentiation ( J:194492 )
• in pIpC-treated bone marrow macrophages
abnormal osteoblast physiology ( J:194492 )
• osteoblasts from the long bones of pIpC-treated mice exhibit increased ALP activity and formed more mineralized bone nodules compared with control cells
• however, osteoblast proliferation is normal

immune system
abnormal osteoclast differentiation ( J:194492 )
• in pIpC-treated bone marrow macrophages
increased osteoclast cell number ( J:194492 )
• in pIpC-treated mice
abnormal osteoclast physiology ( J:194492 )
• pIpC-treated mice exhibit reduced resorption pit depths compared with control mice

hematopoietic system
abnormal osteoclast differentiation ( J:194492 )
• in pIpC-treated bone marrow macrophages
increased osteoclast cell number ( J:194492 )
• in pIpC-treated mice
abnormal osteoclast physiology ( J:194492 )
• pIpC-treated mice exhibit reduced resorption pit depths compared with control mice




Genotype
MGI:5492068
cn4
Allelic
Composition		 Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsktm1.1Rbar mutation (0 available); any Ctsk mutation (31 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increase in cross-sectional bone volume and cortical bone volume in Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Itgam-cre)AJva/0 femurs but not in Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Mx1-cre)1Cgn/0 or Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 femurs

skeleton
skeleton phenotype ( J:194492 )
N
• mice exhibit normal bone density




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory