Phenotypes associated with this allele

• Allele Symbol: Trim27^tm1Sis
• Allele Name: targeted mutation 1, Shunsuke Ishii
• Allele ID: MGI:5494137
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim27^tm1Sis/Trim27^tm1Sis	B6.Cg-Trim27^tm1Sis	MGI:5563538

Genotype
MGI:5563538

hm1

• Allelic Composition: Trim27^tm1Sis/Trim27^tm1Sis
• Genetic Background: B6.Cg-Trim27^tm1Sis

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:206755 )

• fewer mice injected with TNF-alpha and GalN die compared with wild-type mice

cellular

decreased sensitivity to induced cell death ( J:206755 )

• in mouse embryonic fibroblasts treated with TNF-alpha and CHX

• however, Fas-, TRAIL and etoposide-induced apoptosis is normal

decreased hepatocyte apoptosis ( J:206755 )

• in TNF-alpha and GalN-injected mice compared with wild-type mice

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:206755 )

• in TNF-alpha and GalN-injected mice compared with wild-type mice

decreased circulating aspartate transaminase level ( J:206755 )

• in TNF-alpha and GalN-injected mice compared with wild-type mice

liver/biliary system

decreased hepatocyte apoptosis ( J:206755 )

• in TNF-alpha and GalN-injected mice compared with wild-type mice