Phenotypes associated with this allele

• Allele Symbol: Rax^{tm1.1(rTA,tetO-cre)Lan}
• Allele Name: targeted mutation 1.1, Richard A Lang
• Allele ID: MGI:5494255
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Rax^tm1.1(rTA,tetO-cre)Lan/?	involves: 129/Sv * C57BL/6 * SJL	MGI:5494276

Genotype
MGI:5494276

ot1

• Allelic Composition: Rax^{tm1.1(rTA,tetO-cre)Lan}/?
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:195568 )

• if pregnant females are not provided with doxycycline in their diet, all mutant offspring are runted, postulated to be due to cre-mediated cellular toxicity

vision/eye

microphthalmia ( J:195568 )

• when doxycycline withdrawal is performed at E4, mutant embryos analyzed at E11.5 have smaller eyes than wild type littermates: this is postulated to be due to cre-mediated cellular toxicity

anophthalmia ( J:195568 )

• if pregnant females are not provided with doxycycline in their diet, all mutant offspring lack observable eye structures, postulated to be due to cre-mediated cellular toxicity

• mutants resemble Rax^tm1.2Mjam knock-outs