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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Brca1tm2Rjbr
targeted mutation 2, Richard J Baer
MGI:5494434
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Brca1tm2Rjbr/Brca1tm2Rjbr involves: 129 MGI:5494470
hm2
 		Brca1tm2Rjbr/Brca1tm2Rjbr involves: 129 * C57BL/6 MGI:5494451
cn3
 		Brca1tm2.1Cxd/Brca1tm2Rjbr
Trp53tm3Tyj/Trp53+
Waptm1(cre)Arge/Wap+ 		involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:5494458
cn4
 		Brca1tm1Thl/Brca1tm2Rjbr
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5494465


Genotype
MGI:5494470
hm1
Allelic
Composition		 Brca1tm2Rjbr/Brca1tm2Rjbr
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Rjbr mutation (1 available); any Brca1 mutation (114 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:197743 )
• mice are tumor prone




Genotype
MGI:5494451
hm2
Allelic
Composition		 Brca1tm2Rjbr/Brca1tm2Rjbr
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Rjbr mutation (1 available); any Brca1 mutation (114 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:177853 )
N
• mice are born at the expected Mendelian ratio

reproductive system

cellular
abnormal centrosome morphology ( J:177853 )
• mouse embryonic fibroblasts exhibit increased cells with greater than 2 centrosomes
decreased fibroblast proliferation ( J:177853 )
• of mouse embryonic fibroblasts
early cellular replicative senescence ( J:177853 )
• in mouse embryonic fibroblasts

neoplasm
increased tumor incidence ( J:177853 )
• 49 of 72 mice develop tumors




Genotype
MGI:5494458
cn3
Allelic
Composition		 Brca1tm2.1Cxd/Brca1tm2Rjbr
Trp53tm3Tyj/Trp53+
Waptm1(cre)Arge/Wap+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2.1Cxd mutation (1 available); any Brca1 mutation (114 available)
Brca1tm2Rjbr mutation (1 available); any Brca1 mutation (114 available)
Trp53tm3Tyj mutation (3 available); any Trp53 mutation (240 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:177853 )
• 308 days compared with 380 days in Trp53tm3Tyj Waptm1(cre)Arge double heterozygotes
• however, latency is similar to in Brca1tm2.1Cxd/Brca1tm2.1Cxd Trp53tm3Tyj/Trp53+ Waptm1(cre)Arge/Wap+




Genotype
MGI:5494465
cn4
Allelic
Composition		 Brca1tm1Thl/Brca1tm2Rjbr
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Brca1tm2Rjbr mutation (1 available); any Brca1 mutation (114 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:177853 )
• 45 days compared with 68 days in Krastm4Tyj/Kras+ Tg(Ipf1-cre)6Tuv Trp53tm1Thl/Trp53tm1Thl
• however, latency is similar to in Brca1tm1Thl/Brca1tm1Thl Krastm4Tyj/Kras+ Tg(Ipf1-cre)6Tuv Trp53tm1Thl/Trp53tm1Thl




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory