All Phenotypes Brca1<tm3.1Rjbr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Brca1^tm3.1Rjbr
targeted mutation 3.1, Richard J Baer
MGI:5494435

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brca1^tm3.1Rjbr/Brca1^tm3.1Rjbr	involves: 129 * C57BL/6	MGI:5494453
ht2	Brca1^tm2Arge/Brca1^tm3.1Rjbr	involves: 129 * C57BL/6	MGI:5494454
cn3	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5494461
cn4	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	MGI:5494459
cn5	Brca1^tm1Thl/Brca1^tm3.1Rjbr Kras^tm4Tyj/Kras⁺ Trp53^tm1Thl/Trp53^tm1Thl Tg(Pdx1-cre)6Tuv/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5494462

Allelic Composition	Brca1^tm3.1Rjbr/Brca1^tm3.1Rjbr
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:177853 )

N	• mice are born at the expected Mendelian ratio and survived to adulthood

reproductive system

azoospermia ( J:177853 )

• seminiferous tubules lack elongated spermatids and spermatozoa

small testis ( J:177853 )

arrest of spermatogenesis ( J:177853 )

male infertility ( J:177853 )

growth/size/body

decreased body weight ( J:177853 )

• modest

cellular

cellular phenotype ( J:177853 )

N	• mouse embryonic fibroblasts exhibit normal cellular proliferation, chromosomal stability, senescence induction, centrosome number, spindle formation, resistance to genotoxic stress and ubiquitin foci formation at sites of DNA damage

azoospermia ( J:177853 )

• seminiferous tubules lack elongated spermatids and spermatozoa

neoplasm

neoplasm ( J:177853 )

N	• mice do not exhibit increased spontaneous tumor formation

endocrine/exocrine glands

small testis ( J:177853 )

Allelic Composition	Brca1^tm2Arge/Brca1^tm3.1Rjbr
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Arge mutation (0 available); any Brca1 mutation (114 available)
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:177853 )

N	• mice do not exhibit increased spontaneous tumor formation

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Trp53^tm3Tyj/Trp53⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (1 available); any Brca1 mutation (114 available)
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (114 available)
Trp53^tm3Tyj mutation (3 available); any Trp53 mutation (240 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor latency ( J:177853 )

• compared with Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Trp53^tm3Tyj/Trp53^tm3Tyj Wap^tm1(cre)Arge/Wap^tm1(cre)Arge

Allelic Composition	Brca1^tm2.1Cxd/Brca1^tm3.1Rjbr Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2.1Cxd mutation (1 available); any Brca1 mutation (114 available)
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (114 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:177853 )

N	• unlike in mice with Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Wap^tm1(cre)Arge/Wap⁺, mice remain tumor free over a 24-month observation period

Allelic Composition	Brca1^tm1Thl/Brca1^tm3.1Rjbr Kras^tm4Tyj/Kras⁺ Trp53^tm1Thl/Trp53^tm1Thl Tg(Pdx1-cre)6Tuv/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (114 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53^tm1Thl mutation (0 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor latency ( J:177853 )

• as in Kras^tm4Tyj/Kras⁺ Tg(Ipf1-cre)6Tuv Trp53^tm1Thl/Trp53^tm1Thlmice succumb to pancreatic tumors with an average latency of 65 days

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24