Analysis Tools
integument
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• at 4 months on the ventral skin starting as gradual thinning of hair
• on the top of its head behind the ears
• however, hair shafts are normal
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• ectatic ducts leading to the surface of the mucocutaneous junction from Meibomian and clitoral glands unlike in control mice
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• sebocytes fail to fully disintegrate in the sebaceous gland and form clustered eosinophilic remnants in the infundibula
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• in the skin
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• older mice exhibit follicular dystrophy associated with inflammatory cells unlike in control mice
• follicular scars extend below sebaceous glands in the dermis unlike in control mice
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• altered skin surface lipids (lower wax monoesters, unsaturated fatty acids and glycerophosphocholines but higher saturated fatty acids, triacylglycerols, ceramides and (lyso)phosphocholines
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• very few clear cytoplasmic vacuoles instead containing irregular material
• with swollen mitochondria
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homeostasis/metabolism
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• altered skin surface lipids (lower wax monoesters, unsaturated fatty acids and glycerophosphocholines but higher saturated fatty acids, triacylglycerols, ceramides and (lyso)phosphocholines
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endocrine/exocrine glands
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• sebocytes fail to fully disintegrate in the sebaceous gland and form clustered eosinophilic remnants in the infundibula
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• very few clear cytoplasmic vacuoles instead containing irregular material
• with swollen mitochondria
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• in the skin
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| alopecia | DOID:987 |
OMIM:PS203655 |
J:267002 | |
