Phenotypes associated with this allele

• Allele Symbol: Lrp1^{tm1.1(KOMP)Wtsi}
• Allele Name: targeted mutation 1.1, Wellcome Trust Sanger Institute
• Allele ID: MGI:5494466
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrp1^tm1.1(KOMP)Wtsi/Lrp1^tm1.1(KOMP)Wtsi	C57BL/6N-Lrp1^tm1.1(KOMP)Wtsi/J	MGI:5631277
ht2	Lrp1^tm1.1(KOMP)Wtsi/Lrp1^+	C57BL/6N-Lrp1^tm1.1(KOMP)Wtsi/J	MGI:5631276

Genotype
MGI:5631277

hm1

• Allelic Composition: Lrp1^{tm1.1(KOMP)Wtsi}/Lrp1^{tm1.1(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Lrp1^{tm1.1(KOMP)Wtsi}/J
• Cell Lines: EPD0415_3_C09

Data Sources

IMPC Data for Lrp1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hemorrhage ( J:211773 )

IMPC - JAX

craniofacial

abnormal craniofacial morphology ( J:211773 )

IMPC - JAX

embryo

abnormal embryo size ( J:211773 )

IMPC - JAX

abnormal limb bud morphology ( J:211773 )

IMPC - JAX

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - JAX

limbs/digits/tail

abnormal limb bud morphology ( J:211773 )

IMPC - JAX

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

nervous system

abnormal forebrain morphology ( J:211773 )

IMPC - JAX

vision/eye

microphthalmia ( J:211773 )

IMPC - JAX

Genotype
MGI:5631276

ht2

• Allelic Composition: Lrp1^{tm1.1(KOMP)Wtsi}/Lrp1⁺
• Genetic Background: C57BL/6N-Lrp1^{tm1.1(KOMP)Wtsi}/J
• Cell Lines: EPD0415_3_C09

Data Sources

IMPC Data for Lrp1

cardiovascular system

increased heart weight ( J:211773 )

IMPC - JAX

growth/size/body

increased heart weight ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - JAX

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - JAX