Phenotypes associated with this allele

• Allele Symbol: Agr2^tm1.1Lex
• Allele Name: targeted mutation 1.1, Lexicon Genetics
• Allele ID: MGI:5494472
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agr2^tm1.1Lex/Agr2^tm1.1Lex	involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6	MGI:5494479

Genotype
MGI:5494479

hm1

• Allelic Composition: Agr2^tm1.1Lex/Agr2^tm1.1Lex
• Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mucosal hyperplasia in glandular stomach of Agr2^tm1.1Lex/Agr2^tm1.1Lex mice

mortality/aging

premature death ( J:195573 )

• progressive morbidity necessitates euthanasia

reproductive system

abnormal female reproductive system physiology ( J:195573 )

♀ • female mice breed poorly

digestive/alimentary system

abnormal stomach enteroendocrine cell morphology ( J:195573 )

• decreased expression of enteroendocrine cell markers in the antrum

abnormal large intestine morphology ( J:195573 )

• enlarged

abnormal small intestine morphology ( J:195573 )

• enlarged

• 2-fold increase in weight at 24 weeks

abnormal gastric chief cell morphology ( J:195573 )

• maturation defect of chief cells

abnormal gastric parietal cell morphology ( J:195573 )

• loss of parietal cells by 16 weeks

abnormal stomach glandular epithelium morphology ( J:195573 )

• thickened in the corpus and antrum

stomach mucosa hyperplasia ( J:195573 )

• progressive in the corpus and antrum at 6 to 16 weeks

enlarged stomach ( J:195573 )

• with retention of large amounts of food due to gastric obstruction

• stomach weight is increased 5 times at 18 weeks

intestinal obstruction ( J:195573 )

abnormal intestine physiology ( J:195573 )

• reduced mucin production by the small intestine

• increased cell proliferation

cellular

increased cell proliferation ( J:195573 )

• 3.8- and 2.5-fold in the corpus and antrum, respectively

• in the small and large intestine

• however, no increase in proliferation of parietal, pit and chief cell cells

growth/size/body

decreased body weight ( J:195573 )

• after 12 weeks of age

adipose tissue

decreased total fat pad weight ( J:195573 )

• due to poor nutrition

hematopoietic system

anemia ( J:195573 )

• due to poor nutrition

homeostasis/metabolism

decreased circulating serum albumin level ( J:195573 )

• due to poor nutrition

endocrine/exocrine glands

abnormal stomach enteroendocrine cell morphology ( J:195573 )

• decreased expression of enteroendocrine cell markers in the antrum

abnormal gastric chief cell morphology ( J:195573 )

• maturation defect of chief cells

abnormal gastric parietal cell morphology ( J:195573 )

• loss of parietal cells by 16 weeks