Phenotypes associated with this allele

• Allele Symbol: Klb^tm1.1Akha
• Allele Name: targeted mutation 1.1, Alexei Kharitonenkov
• Allele ID: MGI:5494481
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klb^tm1.1Akha/Klb^tm1.1Akha	C57BL/6-Klb^tm1.1Akha	MGI:5494487

Genotype
MGI:5494487

hm1

• Allelic Composition: Klb^tm1.1Akha/Klb^tm1.1Akha
• Genetic Background: C57BL/6-Klb^tm1.1Akha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating glucose level ( J:195570 )

• FGF21-treated mice fail to exhibit a decrease in glucose serum levels unlike wild-type mice

abnormal circulating insulin level ( J:195570 )

• FGF21-treated mice fail to exhibit a decrease in insulin serum levels unlike wild-type mice

decreased circulating insulin level ( J:195570 )

• in untreated mice

abnormal circulating leptin level ( J:195570 )

• FGF21-treated mice fail to exhibit a decrease in leptin serum levels unlike wild-type mice

abnormal circulating ketone body level ( J:195570 )

• FGF21-treated mice fail to exhibit an increase in beta-hydroxybutyrate serum levels unlike wild-type mice

abnormal circulating cholesterol level ( J:195570 )

• FGF21-treated mice fail to exhibit a decrease in cholesterol serum levels unlike wild-type mice

decreased circulating cholesterol level ( J:195570 )

• in untreated mice

abnormal energy expenditure ( J:195570 )

• FGF21-treated mice fail to exhibit an increase in caloric expenditure unlike wild-type mice

• however, untreated mice exhibit normal energy homeostasis

abnormal circulating adiponectin level ( J:195570 )

• FGF21-treated mice fail to exhibit an increase in adiponectin serum levels unlike wild-type mice

growth/size/body

abnormal body fat mass ( J:195570 )

• FGF21-treated mice exhibit reduced fat mass loss compared with wild-type mice

decreased susceptibility to weight loss ( J:195570 )

• with reduced fat loss following treatment with FGF21

adipose tissue

abnormal body fat mass ( J:195570 )

• FGF21-treated mice exhibit reduced fat mass loss compared with wild-type mice