All Phenotypes Fto<tm1.1Rdc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fto^tm1.1Rdc
targeted mutation 1.1, Roger Cox
MGI:5494489

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fto^tm1.1Rdc/Fto^tm1.1Rdc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5494566
cn2	Fto^tm1.1Rdc/Fto^tm1.1Rdc Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5494567

Allelic Composition	Fto^tm1.1Rdc/Fto^tm1.1Rdc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fto^tm1.1Rdc mutation (2 available); any Fto mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:194922 )

• in mice injected with cre-expressing adenovirus within the mediobasal hypothalamus

behavior/neurological

decreased food intake ( J:194922 )

• in mice injected with cre-expressing adenovirus within the mediobasal hypothalamus

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:194922 )

N	• mice injected with cre-expressing adenovirus within the mediobasal hypothalamus exhibit normal energy expenditure

Allelic Composition	Fto^tm1.1Rdc/Fto^tm1.1Rdc Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fto^tm1.1Rdc mutation (2 available); any Fto mutation (75 available)
Ndor1^{Tg(UBC-cre/ERT2)1Ejb} mutation (6 available); any Ndor1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:194922 )

• 3 of 25 mice die over the 14 weeks after tamoxifen treatment compared with 1 control mouse

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:194922 )

N	• tamoxifen-treated male mice exhibit normal oxygen consumption and energy expenditure

decreased carbon dioxide production ( J:194922 )

• in tamoxifen-treated male mice during the light and dark phases when adjusted for lean body mass

decreased respiratory quotient ( J:194922 )

• in tamoxifen-treated male mice during the light and dark

growth/size/body

decreased lean body mass ( J:194922 )

• in tamoxifen-treated male mice at 9 and 20 weeks

decreased body weight ( J:194922 )

• in tamoxifen-treated male mice at 20 weeks

adipose tissue

increased total body fat amount ( J:194922 )

• in tamoxifen-treated male mice at 20 weeks

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