Phenotypes associated with this allele

• Allele Symbol: Fto^tm1.2Rdc
• Allele Name: targeted mutation 1.2, Roger Cox
• Allele ID: MGI:5494490
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fto^tm1.2Rdc/Fto^tm1.2Rdc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL	MGI:5494568

Genotype
MGI:5494568

hm1

• Allelic Composition: Fto^tm1.2Rdc/Fto^tm1.2Rdc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:194922 )

• less than half of mice survive to weaning

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:194922 )

♂N • male mice exhibit normal carbon dioxide output and energy expenditure when corrected for lean mass

increased oxygen consumption ( J:194922 )

♂ • in male mice corrected for lean body mass in the light phase

decreased respiratory quotient ( J:194922 )

♂ • in male mice during both the light and dark phases

improved glucose tolerance ( J:194922 )

♂ • in male mice

growth/size/body

decreased lean body mass ( J:194922 )

♂ • in male mice

decreased body weight ( J:194922 )

♂ • at 20 weeks in male mice

behavior/neurological

increased food intake ( J:194922 )

♂ • in male mice when normalized to reduced body weight