All Phenotypes Fbxl3<tm1.1Ljp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fbxl3^tm1.1Ljp
targeted mutation 1.1, Louis J Ptacek
MGI:5494565

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxl3^tm1.1Ljp/Fbxl3^tm1.1Ljp	Not Specified	MGI:5494569
cx2	Cry2^tm1Asn/Cry2^tm1Asn Fbxl3^tm1.1Ljp/Fbxl3^tm1.1Ljp	involves: 129P2/OlaHsd	MGI:5494571
cx3	Cry1^tm1Asn/Cry1^tm1Asn Fbxl3^tm1.1Ljp/Fbxl3^tm1.1Ljp	involves: 129P2/OlaHsd	MGI:5494572
cx4	Fbxl3^tm1.1Ljp/Fbxl3^tm1.1Ljp Nr1d1^tm1Schb/Nr1d1^tm1Schb	involves: 129S2/SvPas	MGI:5494570

Allelic Composition	Fbxl3^tm1.1Ljp/Fbxl3^tm1.1Ljp
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl3^tm1.1Ljp mutation (0 available); any Fbxl3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

prolonged circadian behavior period ( J:194250 )

• period is 27.6 hours and heterozygote period is 24.4 hours

Allelic Composition	Cry2^tm1Asn/Cry2^tm1Asn Fbxl3^tm1.1Ljp/Fbxl3^tm1.1Ljp
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry2^tm1Asn mutation (1 available); any Cry2 mutation (40 available)
Fbxl3^tm1.1Ljp mutation (0 available); any Fbxl3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

prolonged circadian behavior period ( J:194250 )

• activity period of 28.2 hours suggesting a lack of interaction between these two genes

Allelic Composition	Cry1^tm1Asn/Cry1^tm1Asn Fbxl3^tm1.1Ljp/Fbxl3^tm1.1Ljp
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cry1^tm1Asn mutation (1 available); any Cry1 mutation (35 available)
Fbxl3^tm1.1Ljp mutation (0 available); any Fbxl3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal circadian behavior period ( J:194250 )

• activity period of 24.3 hours suggesting the period is partially dependent on an interaction between these two genes

Allelic Composition	Fbxl3^tm1.1Ljp/Fbxl3^tm1.1Ljp Nr1d1^tm1Schb/Nr1d1^tm1Schb
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl3^tm1.1Ljp mutation (0 available); any Fbxl3 mutation (43 available)
Nr1d1^tm1Schb mutation (1 available); any Nr1d1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:194250 )

N	• circadian rhythm is near normal at 23.7 hours

abnormal circadian behavior period ( J:194250 )

• unstable onset of activity

• about 10% of double homozygotes become arrhythmic after 2-3 weeks of constant darkness

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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