Phenotypes associated with this allele

• Allele Symbol: Otud7b^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:5494636
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otud7b^tm1Dgen/Otud7b^tm1Dgen	involves: 129 * C57BL/6	MGI:5494650

Genotype
MGI:5494650

hm1

• Allelic Composition: Otud7b^tm1Dgen/Otud7b^tm1Dgen
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:194553 )

• in mice infected with C. rodentium

immune system

decreased activation-induced B cell apoptosis ( J:194553 )

• when stimulated in vitro

increased B cell proliferation ( J:194553 )

• when stimulated in vitro

increased B cell number ( J:194553 )

• following injection of low doses of recombinant BAFF

increased IgA level ( J:194553 )

• in the feces

lymphoid hyperplasia ( J:194553 )

• mice exhibit increase in the size and number of B cell containing colonic patches in tertiary lymphoid structures compared with wild-type mice

• however, injection of LTBR-Ig suppresses lymphoid hyperplasia

decreased susceptibility to bacterial infection ( J:194553 )

• mice are more resistant to C. rodentium infection with reduced bacterial load in organs and feces, amelioration of crypt hyperplasia in the colon, milder weight loss and increased survival compared with wild-type mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:194553 )

• in mice infected with C. rodentium

growth/size/body

decreased body weight ( J:194553 )

• moderate

cellular

decreased activation-induced B cell apoptosis ( J:194553 )

• when stimulated in vitro

increased B cell proliferation ( J:194553 )

• when stimulated in vitro

hematopoietic system

decreased activation-induced B cell apoptosis ( J:194553 )

• when stimulated in vitro

increased B cell proliferation ( J:194553 )

• when stimulated in vitro

increased B cell number ( J:194553 )

• following injection of low doses of recombinant BAFF

increased IgA level ( J:194553 )

• in the feces