Phenotypes associated with this allele

• Allele Symbol: Ston2^tm1Vha
• Allele Name: targeted mutation 1, Volker Haucke
• Allele ID: MGI:5494671
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ston2^tm1Vha/Ston2^tm1Vha	B6.129-Ston2^tm1Vha	MGI:5494675

Genotype
MGI:5494675

hm1

• Allelic Composition: Ston2^tm1Vha/Ston2^tm1Vha
• Genetic Background: B6.129-Ston2^tm1Vha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampal mossy fiber morphology ( J:194336 )

• mossy fibers exhibit increased numbers of synaptic vesicle compared to in wild-type fibers

• however, the number of docked synaptic vesicles and the size and number of active zone are normal

abnormal synaptic vesicle number ( J:194336 )

• mossy fibers exhibit increased numbers of synaptic vesicle compared to in wild-type fibers

• however, the number of docked synaptic vesicles and the size and number of active zone are normal

abnormal synaptic vesicle recycling ( J:194336 )

• synaptic vesicles exhibit selective defect in endocytic sorting of Syt1 but not synaptophysin or synaptobrevin 2, accelerated retrieval and facilitated reformation from endosomes compared with wild-type synaptic vesicles

abnormal synaptic transmission ( J:194336 )

• mice exhibit increased short-term facilitation compared with wild-type mice

enhanced paired-pulse facilitation ( J:194336 )

• with increased frequency facilitation

behavior/neurological

behavior/neurological phenotype ( J:194336 )

N • mice exhibit normal spontaneous alternation in a Y maze, behavior in a dark-light box test and fear conditioning (context and cued)

abnormal response to novel object ( J:194336 )

• mice exhibit a shorter latency to approach a new object compared with wild-type mice

• however, habituation to a novel object is normal

increased vertical activity ( J:194336 )

increased locomotor activity ( J:194336 )

• in an open arena