Phenotypes associated with this allele

• Allele Symbol: Mapk8^tm1.1Jcbr
• Allele Name: targeted mutation 1.1, Jens C Bruning
• Allele ID: MGI:5494695
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapk8^tm1.1Jcbr/Mapk8^tm1.1Jcbr	involves: 129S4/SvJae * C57BL/6	MGI:5494714

Genotype
MGI:5494714

hm1

• Allelic Composition: Mapk8^tm1.1Jcbr/Mapk8^tm1.1Jcbr
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:195844 )

N • mice fed standard chow exhibit normal energy and glucose homeostasis

decreased insulin secretion ( J:195844 )

• in mice fed a high fat diet

decreased susceptibility to diet-induced obesity ( J:195844 )

• in mice fed a high fat diet

decreased circulating leptin level ( J:195844 )

• in mice fed a high fat diet

increased respiratory quotient ( J:195844 )

• during the day and night in mice fed a high fat diet

improved glucose tolerance ( J:195844 )

• in mice fed a high fat diet

increased insulin sensitivity ( J:195844 )

• in mice fed a high fat diet

growth/size/body

decreased body weight ( J:195844 )

• in mice fed a high fat diet

decreased body length ( J:195844 )

• in mice fed a high fat diet

decreased susceptibility to diet-induced obesity ( J:195844 )

• in mice fed a high fat diet

adipose tissue

decreased gonadal fat pad weight ( J:195844 )

• decreased epigonadal fat pad weight in mice fed a high fat diet

decreased percent body fat/body weight ( J:195844 )

• in mice fed a high fat diet

behavior/neurological

decreased food intake ( J:195844 )

• in mice fed a high fat diet

endocrine/exocrine glands

decreased insulin secretion ( J:195844 )

• in mice fed a high fat diet