Phenotypes associated with this allele

• Allele Symbol: Celf6^tm1.2Jdd
• Allele Name: targeted mutation 1.2, Joseph D Dougherty
• Allele ID: MGI:5494708
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Celf6^tm1.2Jdd/Celf6^tm1.2Jdd	involves: C57BL/6	MGI:5494837

Genotype
MGI:5494837

hm1

• Allelic Composition: Celf6^tm1.2Jdd/Celf6^tm1.2Jdd
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:194266 )

N • no indication of increased anxiety

N • general ambulatory and rearing activity normal

N • normal social approach tests

N • normal performance in a Morris water maze

abnormal emotion/affect behavior ( J:194266 )

• swim 25% faster than controls during initial cued tests in a Morris water maze but swim at a normal speed during spatial learning

abnormal response to novel odor ( J:194266 )

• basal response to novel odorant stimulus similar to controls

• after familiarization with a new test odor (chocolate chips) controls increased odor related exploratory behavior and mutant mice did not

decreased vocalization ( J:194266 )

• 60% fewer syllables (calls) per 3 minute interval by pups separated from their dam

growth/size/body

growth/size/body region phenotype ( J:194266 )

N • body weight normal

nervous system

nervous system phenotype ( J:194266 )

N • no gross morphological changes in the brain

homeostasis/metabolism

decreased dopamine level ( J:194266 )

• trend toward lower levels of dopamine in the brain

decreased noradrenaline level ( J:194266 )

• trend toward lower levels of norepinephrine in the brain

decreased serotonin level ( J:194266 )

• decreased serotonin levels in the brain